Harvard Medical School researchers claim to have discovered a way to regenerate the hair cells that enable hearing. According to the academic paper, the potentially groundbreaking hearing loss treatment consists of a “drug-like” molecule cocktail that can effectively restore inner ear’s hearing components.
As detailed in the study, the scientists stimulated hair cell regeneration in mice by “reprogramming” genetic pathways. With the research’s promising results, they hope it can lay the groundwork for future clinical trials.
The human inner ear contains hair-like structures that convert sound vibrations into signals and transmit them to the brain. When these hair cells become damaged due to exposure to loud sounds, they cannot regenerate, leading to hearing loss.
“These findings are extremely exciting because, throughout the history of the hearing loss field, the ability to regenerate hair cells in an inner ear has been the holy grail,” said research team lead Zheng-Yi Chen.
Mammals, including humans, cannot regenerate their hair cells naturally, hindering the development of effective hearing loss treatments. Hair cell damage can result from several factors, such as aging and exposure to loud noise.
According to the World Health Organization, 430 million people suffer from disabled hearing, which accounts for 5% of the world’s population.
Hearing loss is widespread, with various factors contributing to its prevalence. Exposure to loud noise, such as music concerts, is a leading cause of noise-induced hearing loss.
A recent study revealed that half of live music fans who attend gigs and festivals are at risk of hearing loss.